2006
Emmy Award: Outstanding Art Direction for a Multi-Camera Series
Emmy Award: Outstanding Cinematography for a Multi-Camera Series
People's Choice Award: Nominated for Favorite New Television Comedy

2007
Emmy Award: Outstanding Art Direction for a Multi-Camera Series
Emmy Award: Nominated for Outstanding Multi-Camera Picture Editing for a Series
Emmy Award: Nominated for Outstanding Supporting Actor in a Comedy Series (Neil Patrick Harris)
Teen Choice Award: Nominated for Choice TV Actor: Comedy (Neil Patrick Harris)

2008
Emmy Award: Outstanding Art Direction for a Multi-Camera Series
Emmy Award: Nominated for Outstanding Supporting Actor in a Comedy Series (Neil Patrick Harris)
People's Choice Award: Nominated for Favorite Scene Stealing Star (Neil Patrick Harris)
Teen Choice Award: Nominated for Choice TV Show: Comedy
Teen Choice Award: Nominated for Choice TV Actor: Comedy (Neil Patrick Harris)

2009

Golden Globe: Nominated for Best Performance by an Actor in a Supporting Role (Neil Patrick Harris)