I have before and I'm fine. Okay actually that was a coyote I howled back at (it howled at me again because I used to be able to do a super imitation) but it's probably the same concept as with a wolf.
Yea I think its safe because most of the times they are afraid of humans.I howl and sometimes bark back at my Chihuahua Penny and she hates it when I do that!