House and the team treat a knight from a community of men and women living according to the ideals of the High Renaissance; Wilson and an ex start over.
House's team rushes to treat an ailing college football star in time for the patient to try out for the NFL; Foreman's brother (Orlando Jones) makes a surprise visit to the hospital.
Wilson works on a case involving his old friend (Joshua Malina), and he makes a bet with House that the diagnosis is not the return of cancer. Meanwhile, Cuddy has questions about real estate, so she turns to Wilson
It's Thanksgiving, and the team discover they have little to be thankful for in their personal lives. Meanwhile, House takes on the illness of a brilliant physicist who has rejected his intellect to work as a courier.