Kanae-chan from Elfen Lied..Poor Girl. I found this part to be extremely for a number of different reasons..but I still can't help feeling sad every time I see this picture from the scene.
Gundam 00:
Christina Sierra when she got struck by that piece of shrapnel in the back when the bridge was shot by a GN-X(pronounced Jinx).
If that didn't kill her, then getting vaporized by the exploding bridge certainly did. ]:>