Mine won't break up, that's not me being conceited (although I admit if the series had continued I believe they would have stayed together) that's me saying my OTP got together in one of the final scenes of the series finale. I miss Fitch and Sanchez/Detroit 187 soo much.
Meh, my OTP... well they did break up which was inevitable but what's worse was the whole show went even more downhill along with the break-up. I have a new OTP now but I'm talking about House and Cuddy from House, M.D.
Ok, it wouldn´t be pleasant, but I would just wait for a moment when they come to life, because Meredith & Derek break up all the time and those moments when they get back together are always so perfect :D
My 2 OTPs are Doctor&Rose and Spike&Buffy. BTVS is over (not counting the comics, which I have yet to read). In season 6 they had a relationship, but then Buffy broke it off. In season 6, th both hurt each other very badly. Emotionally and physically. But in season 7, they sorta reconciled and become very sweet to each other, but they didn't get together again.
Doctor/Rose were never together, unless you count the clone, but both 10 and Rose are off the show, so....