At the end of the novel, Melinda speaks to Mr. Freeman about her being raped, whereas in the movie, she tells Joyce about it.
In the novel, Andy tries to rape Melinda a second time, whereas in the film, he physically assaults her instead.
The film mentions the story taking place somewhere in the Midwest. The novel takes place in Syracuse, Anderson's hometown.
In the novel, she is raped outside in the trees at the party. In the film, she is raped in Andy's car.
In the book, when Andy tries to rape Melinda a second time, she holds a shard of broken glass up to his neck and says "I said no," but...