Is the anime different from the manga?

I'm not sure what Shugo Chara Chan is, but I know that Shugo Chara has three seasons of episodes. Shugo Chara!, Shugo Chara Doki!, and Shugo Chara Party!
Yes, it's different. The anime has 127 episodes total. The anime basically follows the manga exactly until the third season of Shugo Chara: Shugo Chara Party. Then the anime and manga go their separate ways. Other than that though, their pretty much the same. :)

Shugo Chara Chan! is a different manga about all the Charas. The anime is slightly different. Some scenes are different, like instead of Kuukai's grandpa living on a beach, he lives on a snow resort. I prefer the manga but the anime is A.M.A.Z.I.N.G!!

It's almost totally different. If the anime is following the plot of the manga, I will definitely love it. But, since the anime is full of useless fillers and never end its story, I have no reason to love the anime. The manga is MUCH better, in my opinion. The pure awesome of Shugo Chara is exist in the manga, not in the anime.

Yes

yes