I got hooked to Big MacintoshxTwilight for some odd reason. Fluttershy a close 2nd

Fluttershy

or Cheerliee. I've said this before I don't think there has been any evidence in the series of FlutterMac, but there has been evidence for the other two. Cheerliee being in Hearts and Hooves Day. Twilight actually having many small parts which makes me believe Big Mac has a crush on her. First being in the The Return of Harmony when he licked her face. Second is Lesson Zero when he kept Smarty Pants and third is Ponyville Confidential where the CMC take pictures of Big Mac with Smarty Pants.

Be really cute if this DID work out on its own now, without the "love poison" interfering...the CMC may have been onto something. ;)

Fluttermac is popular because they'd work well together, and though we haven't seen interaction between Bic Mac and Fluttershy yet, that's just because there are so many characters. There are plenty of interactions we haven't gotten to see yet. xD Doesn't mean we won't, or that they've never met/spoken, or don't like one another, or that it wouldn't be a good relationship. On the other hoof, Twilight is a good thought for the reasons mentioned above. And frankly, I've imagined him with each of these mane five, and they all work for me in different ways. (E.g, Rarimac is sort of an "opposites attracting" thing a la Green Acres, Macdash would be surprising but adorable and interesting...and Piemac? Well, that would surprise me the most, but again--very intriguing! Big Mac's a laid-back, sweet guy, and I think he'd be able to see and appreciate the good points of each girl here--and others. Whom he'd fall for, though, remains to be seen...if they come back to the aspect of his love life and don't decide to leave him a bachelor, that is!)

I don't know why I picked this Fluttermac is 2nd

I could see it :D

They just seem like a good couple.