Will Derpy Hooves ever speak again?

Hopefully

I hope! It would be cool if she became more like a side character, not like Mr. and Mrs. Cake are, but a side character. :P

Unlikely.

I'm inclining to agree with Mariofan, I'm afraid. Derpy disappeared from the screen for a long time exactly because she talked and made some dumb parents outraged, cos they found her offensive and retarded. I never understood that. I have bad eyes, but I never found her offensive, but rather cute. Plus if she was featured in an episode, it would make a great lesson of accepting people who are different, or living with a disability. But that's not gonna happen. It's a smaller miracle that she made her way back to the screen in Season 4 and she could be seen multiple times in many episodes. I think the MLP staff won't push their luck and maintain Derpy's current status.

I hope so! I really wanna hear that goofy, silly, DERPY voice of her's again! It fits her PERFECTLY! I LOVE DERPY!!!!!!!!!

But, sadly, It seems unlikely too... *sigh*

Have her talk again Hasbro!

I'll say this.....NOPONY KNOWS!!!!!!!!!!