Brittana, Tike, and Samcedes. No question. Hands down.
I would've added Sugar/Rory and Quinn/Joe, but we hardly see anything in Sugar and Rory's relationship. And Joe and Quinn aren't even a couple. I hope they will be, though.
Klaine and Brittana. They are "something new" on television, and I think that they can really help homosexual or bisexual kids and teens by showing them jow great their lifes can be and that they will find someone and that there are always people who accept them.
Despite the number of interesting relationships glee has had, I have to say KLAINE is the best. Those two slowly fell in love and remained so close that even after such an awful break up, they are still close. Although I sympathize for Brittana fans who love Santana and Brittany together. I think those two should be together too. BUT, i think KLAINE is the best!
I believe Klaine is the best couple ever and that Ryan-twisted mind-Murphy should spent more time evolving other relationships between other characters!