I'd Really Don't Know Why He Hate Brian.Brian is my Man Or Dog I Should Say LOL.And I watched Family Guy New Ep Last Night At the End They were Almost Gonna Made Up When Quagmire Drove Off And Ran over Brian Lol That's My Fact Of Them Two=)
In addition to the habits he mentioned disliking in an actual Family Guy episode, Quagmire hates Bryan because of his wrong place/wrong time comments, like when Bryan mistakes his neice for a boy because of her chemotherapy, or when he sees Quagmire's badly-beaten sister, and complements Quagmire on his taste for rough sex because he didn't know of her relation to Quagmire.
They actually explained that in one episode its cuz Brian uses peter, he dates idiots, hes boring, he doesnt take care of his son like a crap load of reasons :3
Well as you see above me, those answers are correct.
It's stupid that Seth made Quagmire hate Brian for his personality and habits. Quagmire doesn't know Brian that well and you barely see him talk to him. Its just poor writing.