Asuka Tenjouin (Alexis Rhodes) from Yugioh GX looks like a big-eyed Seto Kaiba in drag with a stuffed bra. Doesn't really help that a man does her voice in YGXTAS.
Kino (no last name) From Kino no Tabi. She looks like the lovechild of Haruhi Fujioka & Ciel Phantomhive. We had to be TOLD she was a girl