What do you consider the greatest tragedy in anime?

I would say the death of Toonami in 2008, but there's a chance that [adult swim] might bring it back, so no worries there.

The next tragedy I can think of is the demise of A.D. Vision.

death Of Nagisa and her Daughter,Usiho

To me the biggest tragedy was not going on with Sasameki Koto. The author had really wanted it and so did the fans and the company literally said "We think the ending really showed the concept of "Whispered Words" [Sasameki Koto means whispered words] so we ended it." Now the anime was only 13 episodes one of which was purely an anime exclusive so that's only around 12 chapters shown out of a FIFTY-THREE CHAPTER SERIES. Granted the beginning may be seen as a little shaky and the story itself is pretty slow since there's no kiss until the last chapter but that doesn't make it a bad story. It was just different from the ones where they've been best friends for like 2 months and out of nowhere the one friend says they like the other and then they mack on each other's faces. Yes Sasameki Koto is slow but it makes sense the way the author writes it out and makes it reasonable. That story would have been done some real justice with the magic they can do with animation with the lightning and the voice actors they had [if they had been true to the manga which in the show they actual were almost spot on].

***SPOILER FOR HAKUOUKI***

Death of Okita Souji from Hakuouki

-made me cry for hours, days, weeks, etc
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V that's not how he dies though