Popular high school senior Mike O'Donnell (Zac Efron) seemingly has it all. He is a star athlete headed straight for a college scholarship, until he finds out his high school girlfriend, Scarlett is pregnant he then decides to give his scholarship up to settle down.

Twenty years later, an adult Mike (Matthew Perry) finds his life is not exactly what he expected. He is separated from his wife, Scarlett (Leslie Mann), and living with his best friend Ned Gold (Thomas Lennon), his career at a pharmaceutical company is at a standstill, and his relationships with his teenage children are nonexistent....